The name of this superfamily has been modified since the most recent official CATH+ release (current). At the point of the last release, this superfamily was named:
"P-loop containing nucleotide triphosphate hydrolases
".
FunFam 1235: ATP binding cassette subfamily A member 7
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Apolipoprotein A-I receptor activity GO:0034188
Combining with apolipoprotein A-I and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
2 | Q8IZY2 (/IDA) Q91V24 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q91V24 (/IPI) |
|
Phospholipid transporter activity GO:0005548
Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.
|
1 | Q91V24 (/IDA) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
1 | Q8IZY2 (/IDA) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
1 | Q91V24 (/ISO) |
|
Apolipoprotein A-I receptor activity GO:0034188
Combining with apolipoprotein A-I and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | Q91V24 (/ISO) |
|
Apolipoprotein A-I receptor activity GO:0034188
Combining with apolipoprotein A-I and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | Q7TNJ2 (/ISS) |
|
Phosphatidylcholine floppase activity GO:0090554
Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.
|
1 | Q8IZY2 (/IDA) |
|
Phosphatidylcholine floppase activity GO:0090554
Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.
|
1 | Q91V24 (/ISO) |
|
Phosphatidylserine floppase activity GO:0090556
Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.
|
1 | Q8IZY2 (/IDA) |
|
Phosphatidylserine floppase activity GO:0090556
Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.
|
1 | Q91V24 (/ISO) |
There are 55 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Positive regulation of cholesterol efflux GO:0010875
Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Peptide cross-linking GO:0018149
The formation of a covalent cross-link between or within protein chains.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
|
2 | Q7TNJ2 (/ISS) Q91V24 (/ISS) |
|
Phospholipid efflux GO:0033700
The directed movement of a phospholipid out of a cell or organelle.
|
2 | Q8IZY2 (/IDA) Q91V24 (/IDA) |
|
Amyloid-beta formation GO:0034205
The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP).
|
2 | Q8IZY2 (/IMP) Q91V24 (/IMP) |
|
High-density lipoprotein particle assembly GO:0034380
The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.
|
2 | Q7TNJ2 (/ISS) Q91V24 (/ISS) |
|
Protein localization to nucleus GO:0034504
A process in which a protein transports or maintains the localization of another protein to the nucleus.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Apolipoprotein A-I-mediated signaling pathway GO:0038027
A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q8IZY2 (/IDA) Q91V24 (/IDA) |
|
Negative regulation of amyloid precursor protein biosynthetic process GO:0042985
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Plasma membrane raft organization GO:0044857
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of plasma membrane rafts.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Negative regulation of endocytosis GO:0045806
Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Amyloid-beta clearance by cellular catabolic process GO:0150094
The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Positive regulation of amyloid-beta clearance GO:1900223
Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Positive regulation of engulfment of apoptotic cell GO:1901076
Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Negative regulation of amyloid-beta formation GO:1902430
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Positive regulation of phospholipid efflux GO:1902995
Any process that activates or increases the frequency, rate or extent of phospholipid efflux.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Positive regulation of protein localization to cell surface GO:2000010
Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
|
1 | Q91V24 (/IMP) |
|
Positive regulation of cholesterol efflux GO:0010875
Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
|
1 | Q91V24 (/IDA) |
|
Peptide cross-linking GO:0018149
The formation of a covalent cross-link between or within protein chains.
|
1 | Q91V24 (/IDA) |
|
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
|
1 | Q8IZY2 (/IDA) |
|
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
|
1 | Q91V24 (/IMP) |
|
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
|
1 | Q91V24 (/ISO) |
|
Phospholipid efflux GO:0033700
The directed movement of a phospholipid out of a cell or organelle.
|
1 | Q91V24 (/IMP) |
|
Phospholipid efflux GO:0033700
The directed movement of a phospholipid out of a cell or organelle.
|
1 | Q91V24 (/ISO) |
|
Phospholipid efflux GO:0033700
The directed movement of a phospholipid out of a cell or organelle.
|
1 | Q7TNJ2 (/ISS) |
|
Amyloid-beta formation GO:0034205
The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP).
|
1 | Q91V24 (/ISO) |
|
Amyloid-beta formation GO:0034205
The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP).
|
1 | Q7TNJ2 (/ISS) |
|
High-density lipoprotein particle assembly GO:0034380
The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.
|
1 | Q8IZY2 (/IDA) |
|
High-density lipoprotein particle assembly GO:0034380
The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.
|
1 | Q91V24 (/ISO) |
|
Protein localization to nucleus GO:0034504
A process in which a protein transports or maintains the localization of another protein to the nucleus.
|
1 | Q91V24 (/IDA) |
|
Apolipoprotein A-I-mediated signaling pathway GO:0038027
A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q91V24 (/IMP) |
|
Apolipoprotein A-I-mediated signaling pathway GO:0038027
A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q91V24 (/ISO) |
|
Apolipoprotein A-I-mediated signaling pathway GO:0038027
A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q7TNJ2 (/ISS) |
|
Negative regulation of amyloid precursor protein biosynthetic process GO:0042985
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
|
1 | Q91V24 (/IDA) |
|
Plasma membrane raft organization GO:0044857
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of plasma membrane rafts.
|
1 | Q91V24 (/IMP) |
|
Phospholipid translocation GO:0045332
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
|
1 | Q8IZY2 (/IDA) |
|
Phospholipid translocation GO:0045332
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
|
1 | Q91V24 (/ISO) |
|
Negative regulation of endocytosis GO:0045806
Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.
|
1 | Q91V24 (/IMP) |
|
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
|
1 | Q91V24 (/IMP) |
|
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
|
1 | Q8IZY2 (/TAS) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | Q91V24 (/IMP) |
|
Amyloid-beta clearance by cellular catabolic process GO:0150094
The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation.
|
1 | Q91V24 (/IMP) |
|
Positive regulation of amyloid-beta clearance GO:1900223
Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance.
|
1 | Q91V24 (/IMP) |
|
Positive regulation of engulfment of apoptotic cell GO:1901076
Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell.
|
1 | Q91V24 (/IMP) |
|
Negative regulation of amyloid-beta formation GO:1902430
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation.
|
1 | Q91V24 (/IDA) |
|
Negative regulation of amyloid-beta formation GO:1902430
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation.
|
1 | Q91V24 (/IMP) |
|
Regulation of amyloid precursor protein catabolic process GO:1902991
Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.
|
1 | Q8IZY2 (/IMP) |
|
Regulation of amyloid precursor protein catabolic process GO:1902991
Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.
|
1 | Q91V24 (/ISO) |
|
Regulation of amyloid precursor protein catabolic process GO:1902991
Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.
|
1 | Q7TNJ2 (/ISS) |
|
Positive regulation of phospholipid efflux GO:1902995
Any process that activates or increases the frequency, rate or extent of phospholipid efflux.
|
1 | Q91V24 (/IDA) |
|
Positive regulation of protein localization to cell surface GO:2000010
Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface.
|
1 | Q91V24 (/IMP) |
There are 21 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Phagocytic cup GO:0001891
An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q7TNJ2 (/IDA) Q8IZY2 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Glial cell projection GO:0097386
A prolongation or process extending from a glial cell.
|
2 | Q7TNJ2 (/ISS) Q8IZY2 (/ISS) |
|
Phagocytic cup GO:0001891
An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
|
1 | Q91V24 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q91V24 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q7TNJ2 (/ISS) |
|
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | Q8IZY2 (/IDA) |
|
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | Q91V24 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q91V24 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q91V24 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8IZY2 (/TAS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q91V24 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q7TNJ2 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q91V24 (/ISO) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | Q91V24 (/IDA) |
|
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
1 | Q8IZY2 (/IDA) |
|
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
1 | Q91V24 (/ISO) |
|
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
|
1 | Q91V24 (/IDA) |
|
Glial cell projection GO:0097386
A prolongation or process extending from a glial cell.
|
1 | Q91V24 (/IDA) |
