PDB 5uz0

PDB Information

PDB5UZ0
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
Fales, K.R., Njoroge, F.G., Brooks, H.B., Thibodeaux, S., Torrado, A., Si, C., Toth, J.L., Mc Cowan, J.R., Roth, K.D., Thrasher, K.J., Frimpong, K., Lee, M.R., Dally, R.D., Shepherd, T.A., Durham, T.B., Margolis, B.J., Wu, Z., Wang, Y., Atwell, S., Wang, J., Hui, Y.H., Meier, T.I., Konicek, S.A., Geeganage, S.
J. Med. Chem.
HeaderTransferase, Hydrolase
Released2017-02-24
Resolution1.790
CATH Insert Date03 Jun, 2018

PDB Images (21)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 03 Jun, 2018 Chopped
B 03 Jun, 2018 Chopped
C 03 Jun, 2018 Chopped
D 03 Jun, 2018 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5uz0A01 28 Jun, 2018 3.40.50.1380 Assigned
5uz0A02 28 Jun, 2018 3.40.140.20 Assigned
5uz0A03 28 Jun, 2018 3.40.140.20 Assigned
5uz0A04 28 Jun, 2018 1.10.287.440 Assigned
5uz0B01 28 Jun, 2018 3.40.50.1380 Assigned
5uz0B02 28 Jun, 2018 3.40.140.20 Assigned
5uz0B03 28 Jun, 2018 3.40.140.20 Assigned
5uz0B04 28 Jun, 2018 1.10.287.440 Assigned
5uz0C01 28 Jun, 2018 3.40.50.1380 Assigned
5uz0C02 28 Jun, 2018 3.40.140.20 Assigned
5uz0C03 28 Jun, 2018 3.40.140.20 Assigned
5uz0C04 28 Jun, 2018 1.10.287.440 Assigned
5uz0D01 28 Jun, 2018 3.40.50.1380 Assigned
5uz0D02 28 Jun, 2018 3.40.140.20 Assigned
5uz0D03 28 Jun, 2018 3.40.140.20 Assigned
5uz0D04 28 Jun, 2018 1.10.287.440 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P31939 PUR9_HUMAN Homo sapiens Bifunctional purine biosynthesis protein PURH
P31939 PUR9_HUMAN Homo sapiens Bifunctional purine biosynthesis protein PURH
P31939 PUR9_HUMAN Homo sapiens Bifunctional purine biosynthesis protein PURH
P31939 PUR9_HUMAN Homo sapiens Bifunctional purine biosynthesis protein PURH