The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: AICAR transformylase, duplication domain

This superfamily represents the duplication domain in 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferases (AICARFTs, also AICAR transformylase or AICAR Tfase). It has a three layer alpha-beta-alpha sandwich structure.

AICARFT can be part of a bifunctional enzyme (ATIC, the gene product of purH) catalysing the last two steps in de novo purine biosynthesis. ATIC also has an IMP (inosine monophosphate) cyclohydrolase (IMPCHase) functional domain. The bifunctional enzyme forms an intertwined dimer where each monomer is composed of two separate functional domains. AICARFT catalyses the formylation of 5-aminoimidazole-4-carboxamide-ribonucleotide (AICAR) by N-10-formyl-tetrahydrofolate (10-formyl-THF) to produce formyl-AICAR (FAICAR) and THF. ATIC is an attractive candidate for the design of anti-cancer agents, since cancer cells rely more heavily on the de novo purine biosynthesis pathway than normal cells.

PFAM:PF01808, INTERPRO:IPR024051,PMID:11323713,PMID:12501179,PMID:15355974

GO Diversity

Unique GO annotations
34 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
11901 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 92
Domain clusters (>95% seq id): 12
Domain clusters (>35% seq id): 6
Unique PDBs: 18
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 14
Unique EC: 2
Unique GO: 34
Unique Species: 11901