The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
AICARFT can be part of a bifunctional enzyme (ATIC, the gene product of purH) catalysing the last two steps in de novo purine biosynthesis. ATIC also has an IMP (inosine monophosphate) cyclohydrolase (IMPCHase) functional domain. The bifunctional enzyme forms an intertwined dimer where each monomer is composed of two separate functional domains. AICARFT catalyses the formylation of 5-aminoimidazole-4-carboxamide-ribonucleotide (AICAR) by N-10-formyl-tetrahydrofolate (10-formyl-THF) to produce formyl-AICAR (FAICAR) and THF. ATIC is an attractive candidate for the design of anti-cancer agents, since cancer cells rely more heavily on the de novo purine biosynthesis pathway than normal cells.
PFAM:PF01808, INTERPRO:IPR024051,PMID:11323713,PMID:12501179,PMID:15355974
Structures | |
---|---|
Domains: | 92 |
Domain clusters (>95% seq id): | 12 |
Domain clusters (>35% seq id): | 6 |
Unique PDBs: | 18 |
Alignments | |
Structural Clusters (5A): | 1 |
Structural Clusters (9A): | 1 |
FunFam Clusters: | 14 |
Function | |
Unique EC: | 2 |
Unique GO: | 34 |
Taxonomy | |
Unique Species: | 11901 |