PDB 5h25

PDB Information

PDB5H25
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
Huang, Y., Zhang, J., Yu, Z., Zhang, H., Wang, Y., Lingel, A., Qi, W., Gu, J., Zhao, K., Shultz, M.D., Wang, L., Fu, X., Sun, Y., Zhang, Q., Jiang, X., Zhang, J., Zhang, C., Li, L., Zeng, J., Feng, L., Zhang, C., Liu, Y., Zhang, M., Zhang, L., Zhao, M., Gao, Z., Liu, X., Fang, D., Guo, H., Mi, Y., Gabriel, T., Dillon, M.P., Atadja, P., Oyang, C.
J. Med. Chem.
HeaderTransferase/Transferase Inhibitor
Released2016-10-14
Resolution2.880
CATH Insert Date07 May, 2017

PDB Images (7)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped
B 08 May, 2017 Chopped
C 08 May, 2017 Rejected
D 08 May, 2017 Rejected

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5h25A00 14 Dec, 2017 2.130.10.10 Assigned
5h25B00 14 Dec, 2017 2.130.10.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
O75530 EED_HUMAN Homo sapiens Polycomb protein EED
O75530 EED_HUMAN Homo sapiens Polycomb protein EED
Q15910 EZH2_HUMAN Homo sapiens Histone-lysine N-methyltransferase EZH2
Q15910 EZH2_HUMAN Homo sapiens Histone-lysine N-methyltransferase EZH2