CATH Domain 5h25A00

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.130	7 Propeller
	2.130.10	Methylamine Dehydrogenase; Chain H
	2.130.10.10	YVTN repeat-like/Quinoprotein amine dehydrogenase

Domain Context

CATH Clusters

Superfamily	YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family	Polycomb protein eed

Enzyme Information

UniProtKB Entries (1)

EZH2_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase EZH2

PDB Structure

PDB	5H25
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy Huang, Y., Zhang, J., Yu, Z., Zhang, H., Wang, Y., Lingel, A., Qi, W., Gu, J., Zhao, K., Shultz, M.D., Wang, L., Fu, X., Sun, Y., Zhang, Q., Jiang, X., Zhang, J., Zhang, C., Li, L., Zeng, J., Feng, L., Zhang, C., Liu, Y., Zhang, M., Zhang, L., Zhao, M., Gao, Z., Liu, X., Fang, D., Guo, H., Mi, Y., Gabriel, T., Dillon, M.P., Atadja, P., Oyang, C. J. Med. Chem.