PDB 5gvl

PDB Information

PDB5GVL
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourcePlasmodium vivax (strain Salvador I)
Primary Citation
Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures
Schwertz, G., Witschel, M.C., Rottmann, M., Bonnert, R., Leartsakulpanich, U., Chitnumsub, P., Jaruwat, A., Ittarat, W., Schafer, A., Aponte, R.A., Charman, S.A., White, K.L., Kundu, A., Sadhukhan, S., Lloyd, M., Freiberg, G.M., Srikumaran, M., Siggel, M., Zwyssig, A., Chaiyen, P., Diederich, F.
J. Med. Chem.
HeaderTransferase/Transferase Inhibitor
Released2016-09-06
Resolution2.500
CATH Insert Date14 Nov, 2017

PDB Images (10)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
5gvlA01 10 Dec, 2017 3.90.1150.10 Assigned
5gvlA02 10 Dec, 2017 3.40.640.10 Assigned
5gvlB01 10 Dec, 2017 3.90.1150.10 Assigned
5gvlB02 10 Dec, 2017 3.40.640.10 Assigned
5gvlC01 10 Dec, 2017 3.90.1150.10 Assigned
5gvlC02 10 Dec, 2017 3.40.640.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
A5K8L9 A5K8L9_PLAVS Plasmodium vivax Sal-1 Serine hydroxymethyltransferase, putative
A5K8L9 A5K8L9_PLAVS Plasmodium vivax Sal-1 Serine hydroxymethyltransferase, putative
A5K8L9 A5K8L9_PLAVS Plasmodium vivax Sal-1 Serine hydroxymethyltransferase, putative