CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family

Enzyme Information

UniProtKB Entries (1)

A5K8L9
A5K8L9_PLAVS
Plasmodium vivax Sal-1
Serine hydroxymethyltransferase, putative

PDB Structure

PDB 5GVL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures
Schwertz, G., Witschel, M.C., Rottmann, M., Bonnert, R., Leartsakulpanich, U., Chitnumsub, P., Jaruwat, A., Ittarat, W., Schafer, A., Aponte, R.A., Charman, S.A., White, K.L., Kundu, A., Sadhukhan, S., Lloyd, M., Freiberg, G.M., Srikumaran, M., Siggel, M., Zwyssig, A., Chaiyen, P., Diederich, F.
J. Med. Chem.