PDB 5b5t

PDB Information

PDB5B5T
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceEscherichia coli (strain K12)
Primary Citation
Phosphonate-based irreversible inhibitors of human gamma-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity
Kamiyama, A., Nakajima, M., Han, L., Wada, K., Mizutani, M., Tabuchi, Y., Kojima-Yuasa, A., Matsui-Yuasa, I., Suzuki, H., Fukuyama, K., Watanabe, B., Hiratake, J.
Bioorg.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2016-05-18
Resolution1.700
CATH Insert Date09 Oct, 2016

PDB Images (11)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 10 Oct, 2016 Chopped
B 10 Oct, 2016 Chopped
C 10 Oct, 2016 Chopped
D 10 Oct, 2016 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
5b5tA01 14 Oct, 2016 Holding pen
5b5tA02 14 Oct, 2016 1.10.246.130 Assigned
5b5tB00 14 Oct, 2016 Holding pen
5b5tC01 13 Oct, 2016 Holding pen
5b5tC02 13 Oct, 2016 1.10.246.130 Assigned
5b5tD00 13 Oct, 2016 Holding pen

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P18956 GGT_ECOLI Escherichia coli K-12 Glutathione hydrolase proenzyme
P18956 GGT_ECOLI Escherichia coli K-12 Glutathione hydrolase proenzyme
P18956 GGT_ECOLI Escherichia coli K-12 Glutathione hydrolase proenzyme
P18956 GGT_ECOLI Escherichia coli K-12 Glutathione hydrolase proenzyme