PDB Information

Host OrganismEscherichia coli
Gene SourceHepatitis C virus subtype 1a
Primary Citation
Candidate selection and preclinical evaluation culminating in the discovery of Narlaprevir (SCH 900518): A potent, selective and orally efficacious second generation HCV NS3 serine protease inhibitor
Arasappan, A., Bennett, F., Bogen, S.L., Blackman, M., Chen, K., Hendrata, S., Huang, Y., Huelgas, R.M., Nair, L., Padilla, A.I., Pan, W., Pike, R., Pinto, P., Ruan, S., Sannigrahi, M., Velaquez, F., Vibulbhan, B., Wu, W., Yang, W., Saksena, A.K., Girijavallabhan, V., Shih, N.Y., Kong, J., Meng, T., Jin, Y., Wong, J., McNamara, P., Prongay, A., Madison, V., Piwinski, J.J., Cheng, K.C., Morrison, R., Malcolm, B., Tong, X., Ralston, R., Njoroge, F.G.
To be Published
HeaderViral Protein/Inhibitor
CATH Insert Date23 Jan, 2011

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 24 Jan, 2011 Chopped
B 24 Jan, 2011 Rejected
C 24 Jan, 2011 Chopped
D 24 Jan, 2011 Rejected

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
3lonA01 16 Feb, 2011 Assigned
3lonA02 16 Feb, 2011 Assigned
3lonC01 16 Feb, 2011 Assigned
3lonC02 16 Feb, 2011 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q9ELS8 Q9ELS8_9HEPC Hepatitis C virus subtype 1a Genome polyprotein
Q9ELS8 Q9ELS8_9HEPC Hepatitis C virus subtype 1a Genome polyprotein