PDB Information

PDB3KEE
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHepatitis C virus
Primary Citation
Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target
Cummings, M.D., Lindberg, J.D., Lin, T.-I., de Kock, H., Lenz, O., Lilja, E., Fellander, S., Baraznenok, V., Nystrom, S., Nilsson, M., Vrang, L., Edlund, M., Rosenquist, A., Samuelsson, B., Raboisson, P., Simmen, K.
Angew.Chem.Int.Ed.Engl.
HeaderHydrolase
Released2009-10-26
Resolution2.400
CATH Insert Date11 Mar, 2010

PDB Images (17)

PDB Prints

PDB Chains (8)

Chain ID Date inserted into CATH CATH Status
A 11 Mar, 2010 Chopped
B 11 Mar, 2010 Chopped
C 11 Mar, 2010 Chopped
D 11 Mar, 2010 Chopped
E 11 Mar, 2010 Rejected
F 11 Mar, 2010 Rejected
G 11 Mar, 2010 Rejected
H 11 Mar, 2010 Rejected

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
3keeA01 16 Apr, 2010 2.40.10.120 Assigned
3keeA02 16 Apr, 2010 2.40.10.10 Assigned
3keeB01 16 Apr, 2010 2.40.10.120 Assigned
3keeB02 16 Apr, 2010 2.40.10.10 Assigned
3keeC01 16 Apr, 2010 2.40.10.120 Assigned
3keeC02 16 Apr, 2010 2.40.10.10 Assigned
3keeD01 16 Apr, 2010 2.40.10.120 Assigned
3keeD02 16 Apr, 2010 2.40.10.10 Assigned

UniProtKB Entries (8)

Accession Gene ID Taxon Description
P90191 P90191_9HEPC Hepacivirus C Genome polyprotein
P90191 P90191_9HEPC Hepacivirus C Genome polyprotein
P90191 P90191_9HEPC Hepacivirus C Genome polyprotein
Q6GYR8 Q6GYR8_9HEPC Hepacivirus C Genome polyprotein
Q6GYR8 Q6GYR8_9HEPC Hepacivirus C Genome polyprotein
Q6GYR8 Q6GYR8_9HEPC Hepacivirus C Genome polyprotein
Q6GYR8 Q6GYR8_9HEPC Hepacivirus C Genome polyprotein
P90191 P90191_9HEPC Hepacivirus C Genome polyprotein