PDB 3frz

PDB Information

PDB3FRZ
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHepatitis C virus
Primary Citation
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
Li, H., Tatlock, J., Linton, A., Gonzalez, J., Jewell, T., Patel, L., Ludlum, S., Drowns, M., Rahavendran, S.V., Skor, H., Hunter, R., Shi, S.T., Herlihy, K.J., Parge, H., Hickey, M., Yu, X., Chau, F., Nonomiya, J., Lewis, C.
J.Med.Chem.
HeaderTransferase
Released2009-01-08
Resolution1.860
CATH Insert Date12 Mar, 2009

PDB Images (6)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 12 Mar, 2009 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
3frzA01 03 Oct, 2013 Holding pen
3frzA02 03 Oct, 2013 Holding pen
3frzA03 03 Oct, 2013 3.30.70.270 Assigned
3frzA04 03 Oct, 2013 Holding pen

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P26663 POLG_HCVBK Hepatitis C virus (isolate BK) Genome polyprotein