1 keywords

CATH Domain 3frzA01

CATH Classification

Domain Context

CATH Clusters

Superfamily
Functional Family -

PDB Structure

PDB 3FRZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
Li, H., Tatlock, J., Linton, A., Gonzalez, J., Jewell, T., Patel, L., Ludlum, S., Drowns, M., Rahavendran, S.V., Skor, H., Hunter, R., Shi, S.T., Herlihy, K.J., Parge, H., Hickey, M., Yu, X., Chau, F., Nonomiya, J., Lewis, C.
J.Med.Chem.