PDB 2r4f

PDB	2R4F
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia. Pfefferkorn, J.A., Choi, C., Larsen, S.D., Auerbach, B., Hutchings, R., Park, W., Askew, V., Dillon, L., Hanselman, J.C., Lin, Z., Lu, G.H., Robertson, A., Sekerke, C., Harris, M.S., Pavlovsky, A., Bainbridge, G., Caspers, N., Kowala, M., Tait, B.D. J.Med.Chem.
Header	Oxidoreductase
Released	2007-08-31
Resolution	1.700
CATH Insert Date	01 May, 2008

PDB 2r4f

PDB Chain 2r4fA

PDB Chain 2r4fB

PDB Chain 2r4fC

PDB Chain 2r4fD

CATH Domain 2r4fA01

CATH Domain 2r4fA02

CATH Domain 2r4fA03

CATH Domain 2r4fB01

CATH Domain 2r4fB02

CATH Domain 2r4fB03

CATH Domain 2r4fC01

CATH Domain 2r4fC02

CATH Domain 2r4fC03

CATH Domain 2r4fD01

CATH Domain 2r4fD02

CATH Domain 2r4fD03

Domain ID	Date inserted into CATH	Superfamily	CATH Status
2r4fA01	02 May, 2008	1.10.3270.10	Assigned
2r4fA02	02 May, 2008	3.90.770.10	Assigned
2r4fA03	02 May, 2008	3.30.70.420	Assigned
2r4fB01	02 May, 2008	1.10.3270.10	Assigned
2r4fB02	02 May, 2008	3.90.770.10	Assigned
2r4fB03	02 May, 2008	3.30.70.420	Assigned
2r4fC01	02 May, 2008	1.10.3270.10	Assigned
2r4fC02	02 May, 2008	3.90.770.10	Assigned
2r4fC03	02 May, 2008	3.30.70.420	Assigned
2r4fD01	02 May, 2008	1.10.3270.10	Assigned
2r4fD02	02 May, 2008	3.90.770.10	Assigned
2r4fD03	02 May, 2008	3.30.70.420	Assigned

Accession	Gene ID	Taxon	Description
P04035	HMDH_HUMAN	Homo sapiens	3-hydroxy-3-methylglutaryl-coenzyme A reductase
P04035	HMDH_HUMAN	Homo sapiens	3-hydroxy-3-methylglutaryl-coenzyme A reductase
P04035	HMDH_HUMAN	Homo sapiens	3-hydroxy-3-methylglutaryl-coenzyme A reductase
P04035	HMDH_HUMAN	Homo sapiens	3-hydroxy-3-methylglutaryl-coenzyme A reductase