PDB Information

PDB2OC0
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHepatitis C virus
Primary Citation
Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
Prongay, A.J., Guo, Z., Yao, N., Pichardo, J., Fischmann, T., Strickland, C., Myers Jr., J., Weber, P.C., Beyer, B.M., Ingram, R., Hong, Z., Prosise, W.W., Ramanathan, L., Taremi, S.S., Yarosh-Tomaine, T., Zhang, R., Senior, M., Yang, R.S., Malcolm, B., Arasappan, A., Bennett, F., Bogen, S.L., Chen, K., Jao, E., Liu, Y.T., Lovey, R.G., Saksena, A.K., Venkatraman, S., Girijavallabhan, V., Njoroge, F.G., Madison, V.
J.Med.Chem.
HeaderViral Protein
Released2006-12-20
Resolution2.300
CATH Insert Date07 Nov, 2007

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 08 Nov, 2007 Chopped
B 08 Nov, 2007 Rejected
C 08 Nov, 2007 Chopped
D 08 Nov, 2007 Rejected

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
2oc0A01 23 Nov, 2007 2.40.10.120 Assigned
2oc0A02 23 Nov, 2007 2.40.10.10 Assigned
2oc0C01 23 Nov, 2007 2.40.10.120 Assigned
2oc0C02 23 Nov, 2007 2.40.10.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P27958 POLG_HCVH Hepatitis C virus (isolate H) Genome polyprotein
P27958 POLG_HCVH Hepatitis C virus (isolate H) Genome polyprotein
P27958 POLG_HCVH Hepatitis C virus (isolate H) Genome polyprotein
P27958 POLG_HCVH Hepatitis C virus (isolate H) Genome polyprotein