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CATH Superfamily 3.30.70.1230

Nucleotide cyclase, GGDEF domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Nucleotide cyclase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Adenylate cyclase
1049 - - 86.8
2
Adenylate cyclase
867
3D
 3maaA00 - 74.6
3
Adenylate cyclase
623
3D
 3maaB00 - 78.1
4
Guanylate cyclase
380 - - 85.9
5
Guanylate cyclase soluble subunit beta-1
274
3D
 4ni2B00 - 86.7
6
Adenylate cyclase
269 - - 80.8
7
Guanylate cyclase soluble subunit alpha-3
265
3D
 4ni2A00 - 89.2
8
Adenylate cyclase type 9
253 - - 87.7
9
Adenylate cyclase
252 - - 73.9
10
Adenylate cyclase 2
236 - - 37.8
11
Adenylate cyclase
232 - - 56.3
12
Adenylate cyclase
227 - - 50.0
13
Guanylate cyclase
217 - - 79.8
14
adenylate cyclase type 9
216 - - 84.6
15
Guanylate cyclase
199 - - 88.0
17
Adenylate cyclase type 10
160
3D
 5iv4A02 - 97.2
16
Adenylate/guanylate cyclase domain-containing protein
154 - - 95.0
18
Adenylate cyclase AcyA
118 - - 70.5
21
Adenylate cyclase type 10
115
3D
 5iv4A01 - 96.1
19
Guanylate cyclase
99 - - 75.4
20
Adenylate cyclase
98 - - 48.9
22
Receptor-type adenylate cyclase GRESAG 4, putative
79
3D
 1fx2A00 - 94.1
23
Guanylate cyclase
77 - - 73.6
24
ACXA, isoform A
74 - - 87.1
25
Adenylate cyclase 1
67
3D
 3r5gB00 - 56.2
33
Adenylate cyclase
65
3D
 4p2xB00 - 91.0
26
Guanylyl cyclase, putative
56 - - 83.6
27
ACXA, isoform A
53 - - 82.2
28
Guanylate cyclase
52 - - 82.6
30
Si:ch211-215j19.12
47 - - 90.5
29
Adenylate cyclase type 2
47 - - 30.5
31
Adenylate cyclase type 7
46 - - 59.5
32
Adenylyl cyclase 78C
46 - - 86.2
34
Adenylyl cyclase beta
36 - - 21.4
35
Guanylate cyclase
34 - - 81.0
36
Adenylate/guanylate cyclase catalytic domain protein
33 - - 86.1
37
Guanylate cyclase
32 - - 41.4
38
soluble guanylate cyclase 89Da
32 - - 72.5
39
Guanylate cyclase
32 - - 47.0
40
Ca
2+
31 - - 45.5
41
Adenylate cyclase 1
28 - - 73.9
43
Luxr family transcriptional regulator
24 - - 38.6
42
Adenylate cyclase
24 - - 81.3
44
Guanylate cyclase
24 - - 65.5
45
Phospholipid-transporting ATPase
23 - - 83.7
46
Luxr family transcriptional regulator
23 - - 24.9
47
Adenylate/guanylate cyclase catalytic domain protein
20 - - 0.0
48
Phospholipid-transporting ATPase, putative
19 - - 71.6
50
Guanylate cyclase
19 - - 87.7
49
Guanylyl cyclase
19 - - 0.6
70
Probable lignin peroxidase lipJ
19
3D
 1ybuD00 - 12.9
51
Soluble guanylate cyclase 88E
18 - - 8.6
54
Guanylate cyclase
18 - - 35.3
52
Adenylate/guanylate cyclase catalytic domain protein
18 - - 0.6
53
Guanylate cyclase, putative
18 - - 68.5
55
Adenylyl cyclase beta
17 - - 92.3
59
Guanylate cyclase
15 - - 89.1
57
Guanylate cyclase
15 - - 71.1
56
Putative adenylate cyclase
15 - - 83.3
58
Photoactivated adenylate cyclase subunit beta-like protein FB
15 - - 67.4
61
Adenylate cyclase
13 - - 56.5
76
pH-sensitive adenylate cyclase Rv1264
13
3D
 1y11A02 - 9.1
62
Predicted protein
13 - - 89.2
60
Adenylate cyclase
13 - - 31.7
64
Adenylate cyclase type 9
12 - - 62.5
67
Adenylate/guanylate cyclase catalytic domain protein
12 - - 4.5
66
Predicted protein
12 - - 76.6
65
Photoactivated adenylate cyclase subunit alpha-like protein ST-
12 - - 60.4
63
Adenylate cyclase
12 - - 12.2
68
Putative ATPase
12 - - 23.3
71
Adenylate cyclase
ATP pyrophosphate-lyase
11 - - 13.3
69
Adenylyl CYclase
11 - - 32.5
72
Adenylate/guanylate cyclase domain-containing protein
10 - - 1.2
73
Soluble guanylate cyclase gcy-37
10 - - 58.3
75
Adenylate/guanylate cyclase domain-containing protein
9 - - 45.8
74
Guanylate cyclase
9 - - 34.6
81
Predicted protein
8 - - 73.5
84
Adenylate cyclase
8 - - 32.7
82
Adenylate cyclase type 6
8 - - 77.6
77
Adenylyl CYclase
8 - - 16.5
83
Guanylate cyclase
8 - - 46.1
78
Adenylyl CYclase
8 - - 20.7
80
LuxR family transcriptional regulator
8 - - 39.7
79
Soluble guanylate cyclase gcy-31
8 - - 16.9
91
Guanylate cyclase
7 - - 68.5
87
Predicted protein
7 - - 72.0
85
Adenylate/guanylate cyclase domain-containing protein
7 - - 15.4
86
Adenylate cyclase type 10-like Protein
7 - - 74.4
88
Guanylate cyclase
7 - - 74.8
90
Guanylate cyclase
7 - - 66.3
89
AAA ATPase domain protein
7 - - 14.9
94
Guanylate cyclase soluble subunit beta-1
6 - - 66.1
96
Guanylate cyclase
6 - - 78.8
92
Adenylate cyclase 1
6 - - 10.9
95
Adenylate cyclase, putative
6 - - 70.2
93
7TM diverse intracellular signaling
6 - - 0.0
97
Guanylate cyclase
5 - - 54.8
102
Guanylate cyclase
5 - - 16.3
104
Adenylate cyclase
5 - - 12.4
98
Adenylate/guanylate cyclase catalytic domain protein
5 - - 7.3
103
Adenylate cyclase
5 - - 10.4
106
Guanylate cyclase
5 - - 21.4
101
Adenylate cyclase
5 - - 52.4
105
Receptor-type guanylate cyclase gcy-21
5 - - 45.3
100
7TM diverse intracellular signaling
5 - - 10.2
99
Adenylate cyclase EC 4611
5 - - 11.6
113
Adenylate cyclase-like protein
4 - - 10.9
111
Predicted protein
4 - - 25.9
116
Uncharacterized protein
4 - - 62.7
115
Soluble guanylate cyclase gcy-35
4 - - 67.5
117
Guanylate cyclase
4 - - 67.3
109
Uncharacterized protein
4 - - 3.6
110
Adenylate/guanylate cyclase catalytic domain protein
4 - - 1.1
118
Predicted protein
4 - - 65.5
112
Putative adenylate cyclase 3
4 - - 8.2
107
Guanylate cyclase
4 - - 84.6
114
Adenylate cyclase 8
brain
4 - - 50.6
119
Guanylate cyclase
4 - - 36.2
108
Adenylate cyclase CyaC
4 - - 20.0
121
Adenylate/guanylate cyclase domain-containing protein
3 - - 7.0
126
Two-component response regulator
3 - - 5.0
123
Adenylate cyclase
ATP pyrophosphate-lyase Adenylyl cyclase
3 - - 0.0
130
Adenylate cyclase
3 - - 7.0
133
Predicted protein
3 - - 57.6
128
Adenylate/guanylate cyclase domain-containing protein
3 - - 0.6
120
Olfactory guanylyl cyclase GC-D
3 - - 29.9
131
Protein kinase, putative
3 - - 4.4
127
Chlamyopsin-5 sensory rhodopsin
3 - - 0.0
125
Predicted protein
3 - - 31.7
122
Adenylate cyclase 1
3 - - 6.6
134
Predicted protein
3 - - 73.3
129
Adenylate/guanylate cyclase
3 - - 0.6
124
Adenylate/guanylate cyclase
3 - - 0.0
132
Uncharacterized protein
3 - - 52.4
180
Predicted protein
2 - - 1.7
188
Predicted protein
2 - - 0.0
161
Predicted protein
2 - - 0.0
135
Predicted protein
2 - - 35.6
166
Predicted protein
2 - - 0.0
143
Adenylate/guanylate cyclase domain-containing protein
2 - - 0.0
204
Uncharacterized protein
2 - - 40.5
151
Adenylate cyclase 10
2 - - 7.9
156
Photoactivated adenylate cyclase subunit beta-like protein 1224-5/9F
2 - - 20.2
137
Guanylate cyclase
2 - - 44.7
173
Adenylate/guanylate cyclase domain-containing protein
2 - - 0.0
187
Adenylate/guanylate cyclase domain-containing protein
2 - - 0.0
199
Adenylate cyclase 3
2 - - 18.2
163
Predicted protein
2 - - 0.0
194
Predicted protein
2 - - 0.0
141
Adenylate cyclase
2 - - 0.0
146
Atrial natriuretic peptide receptor, putative
2 - - 41.4
185
Adenylate/guanylate cyclase domain-containing protein
2 - - 0.0
138
Guanylate cyclase
2 - - 20.2
153
Guanylyl cyclase, membrane
2 - - 7.2
176
Adenylate/guanylate cyclase domain-containing protein
2 - - 0.0
171
Blr1670 protein
2 - - 0.0
158
Uncharacterized protein
2 - - 38.0
177
Predicted protein
2 - - 0.0
145
Adenylate cyclase, aggregation specific
2 - - 31.7
150
Guanylate cyclase
2 - - 0.0
192
Predicted protein
2 - - 0.0
147
Guanylyl cyclase, membrane
2 - - 11.3
175
Protein kinase, putative
2 - - 0.0
160
Predicted protein
2 - - 39.0
186
Mitogen-activated protein kinase-like protein
2 - - 8.4
181
Protein kinase, putative
2 - - 0.0
168
Adenylate cyclase, terminal-differentiation specific
2 - - 6.0
136
Uncharacterized protein
2 - - 44.6
170
Adenylate cyclase
2 - - 0.0
165
adenylate cyclase type 10-like
2 - - 0.0
178
Predicted protein
2 - - 0.7
157
Uncharacterized protein
2 - - 33.7
140
Ca
2+
2 - - 10.8
167
Predicted protein
2 - - 0.0
202
Uncharacterized protein
2 - - 33.8
148
Adenylate cyclase type 10
2 - - 0.0
155
Guanylate cyclase
2 - - 0.0
183
Predicted protein
2 - - 0.0
205
Adenylyl cyclase class-3/4/guanylyl cyclase
2 - - 40.4
198
Predicted protein
2 - - 0.0
152
Uncharacterized protein
2 - - 0.0
190
Predicted protein
2 - - 0.0
162
Predicted protein
2 - - 0.0
139
Predicted protein
2 - - 19.7
172
Predicted protein
2 - - 0.0
184
Predicted protein
2 - - 0.0
189
Predicted protein
2 - - 0.0
197
Predicted protein
2 - - 0.0
142
Blr5637 protein
2 - - 1.8
200
Guanylate cyclase
2 - - 28.7
195
Predicted protein
2 - - 11.6
182
Adenylyl cyclase class-3/4/guanylyl cyclase
2 - - 0.0
174
Gcy-36
2 - - 0.0
203
Guanylate cyclase
2 - - 36.4
179
Predicted protein
2 - - 0.0
196
Predicted protein
2 - - 2.8
191
Predicted protein
2 - - 0.8
144
Adenylate cyclase 3
2 - - 12.0
149
Uncharacterized protein
2 - - 0.0
159
Uncharacterized protein
2 - - 41.4
206
Guanylate cyclase
2 - - 27.1
201
Guanylate cyclase 2d
2 - - 31.4
154
Soluble guanylyl cyclase beta1
2 - - 1.1
164
Adenylyl cyclase class-3/4/guanylyl cyclase
2 - - 0.0
193
Predicted protein
2 - - 0.0
169
Adenylyl cyclase class-3/4/guanylyl cyclase
2 - - 0.0
245
Atrial natriuretic peptide receptor, putative
1 - - 0.0
228
Adenylate cyclase
1 - - 0.0
233
Uncharacterized protein
1 - - 0.0
258
Predicted protein
1 - - 0.0
277
Adenylate cyclase 5-like
1 - - 0.0
215
Guanylate cyclase
1 - - 0.0
220
Atrial natriuretic peptide receptor, putative
1 - - 0.0
250
Blr6052 protein
1 - - 0.0
275
Predicted protein
1 - - 0.0
217
Adenylate cyclase, putative
1 - - 0.0
260
Predicted protein
1 - - 0.0
247
Predicted protein
1 - - 0.0
286
Guanylate cyclase
1 - - 0.0
281
Guanylate cyclase
1 - - 0.0
268
Uncharacterized protein
1 - - 0.0
209
Predicted protein
1 - - 0.0
236
Uncharacterized protein
1 - - 0.0
270
Uncharacterized protein
1 - - 0.0
265
Uncharacterized protein
1 - - 0.0
231
Predicted protein
1 - - 0.0
227
Uncharacterized protein
1 - - 0.0
278
Predicted protein
1 - - 0.0
257
4-phytase
1 - - 0.0
267
Predicted protein
1 - - 0.0
210
Uncharacterized protein
1 - - 0.0
240
Uncharacterized protein
1 - - 0.0
255
Uncharacterized protein
1 - - 0.0
283
Predicted protein
1 - - 0.0
218
Uncharacterized protein
1 - - 0.0
248
Predicted protein
1 - - 0.0
225
AGAP012805-PA
1 - - 0.0
280
Guanylate cyclase
1 - - 0.0
243
Adenylyl cyclase
1 - - 0.0
213
Guanylate cyclase
1 - - 0.0
261
Predicted protein
1 - - 0.0
235
Uncharacterized protein
1 - - 0.0
266
Predicted protein
1 - - 0.0
251
Uncharacterized protein
1 - - 0.0
256
Adenylyl cyclase class-3/4/guanylyl cyclase
1 - - 0.0
221
Uncharacterized protein
1 - - 0.0
226
Predicted protein
1 - - 0.0
237
Adenylate cyclase, putative
1 - - 0.0
273
Uncharacterized protein
1 - - 0.0
241
Guanylate cyclase
1 - - 0.0
246
Predicted protein
1 - - 0.0
263
Predicted protein
1 - - 0.0
211
Uncharacterized protein
1 - - 0.0
216
Predicted protein
1 - - 0.0
285
Guanylate cyclase
1 - - 0.0
238
Adenylate cyclase, putative
1 - - 0.0
253
Guanylate cyclase
1 - - 0.0
223
Uncharacterized protein
1 - - 0.0
276
Predicted protein
1 - - 0.0
271
Predicted protein
1 - - 0.0
230
Uncharacterized protein
1 - - 0.0
274
Predicted protein
1 - - 0.0
282
Uncharacterized protein
1 - - 0.0
279
Uncharacterized protein
1 - - 0.0
244
Predicted protein
1 - - 0.0
214
Uncharacterized protein
1 - - 0.0
207
Predicted protein
1 - - 0.0
219
Uncharacterized protein
1 - - 0.0
249
Guanylate cyclase
1 - - 0.0
229
Uncharacterized protein
1 - - 0.0
259
Putative regulatory protein
1 - - 0.0
254
Guanylate cyclase
1 - - 0.0
224
Uncharacterized protein
1 - - 0.0
264
Predicted protein
1 - - 0.0
269
Guanylyl cyclase 3
1 - - 0.0
232
Uncharacterized protein
1 - - 0.0
208
Guanylate cyclase
1 - - 0.0
222
Uncharacterized protein
1 - - 0.0
252
Protein kinase, putative
1 - - 0.0
262
Uncharacterized protein
1 - - 0.0
239
Soluble adenylyl cyclase
1 - - 0.0
234
Predicted protein
1 - - 0.0
284
Uncharacterized protein
1 - - 0.0
272
Guanylate cyclase
1 - - 0.0
212
Uncharacterized protein
1 - - 0.0
242
Predicted protein
1 - - 0.0
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