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CATH Superfamily 1.25.10.60

Rad61, Wapl domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rad61, Wapl domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Rad61, Wapl domain

This superfamily comprises the Wapl domain usually found at the C-terminus of fungal Wpl1 proteins (also known as Rad61), which are subunits of a complex that inhibits sister chromatid cohesion. These proteins are members of the cohesin complex. The Wapl domain binds to the ATPase head domain of cohesin subunit Smc3 PMID:23395900. The Wapl gene was initially identified in Drosophila as a controller of heterochromatin structure and cohesion. Wapl is involved in the destabilisation of chromatin-bound cohesin in an acetylation-dependent manner, although the molecular mechanisms of this complex pathway are not fully understood.

INTERPRO:IPR031550, PFAM:PF16997,DOI:10.1038/emboj.2013.16

GO Diversity

Unique GO annotations
4 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
44 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 3
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 4
Taxonomy
Unique Species: 44
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