CATH Domain 6hu9P01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.5	Single alpha-helices involved in coiled-coils or other helix-helix interfaces
	1.20.5.270	Ubiquinol cytochrome reductase, transmembrane domain

Domain Context

CATH Clusters

Superfamily	Ubiquinol cytochrome reductase, transmembrane domain
Functional Family	Cytochrome b-c1 complex subunit Rieske, mitochondrial

Enzyme Information

7.1.1.8

Quinol--cytochrome-c reductase.

based on mapping to UniProt P08067

Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2).

-!- The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. -!- It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. -!- The mammalian enzyme contains cytochromes b-562, b-566 and c(1), and a 2-iron ferredoxin. -!- Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non- cytoplasmic compartment (cf. EC 1.6.99.3). -!- Formerly EC 1.10.2.2.

UniProtKB Entries (1)

P04039

COX8_YEAST

Saccharomyces cerevisiae S288C

Cytochrome c oxidase polypeptide VIII, mitochondrial

PDB Structure

PDB	6HU9
External Links	PDBSum Proteopedia
Method	ELECTRON MICROSCOPY
Organism
Primary Citation	Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1. Hartley, A.M., Lukoyanova, N., Zhang, Y., Cabrera-Orefice, A., Arnold, S., Meunier, B., Pinotsis, N., Marechal, A. Nat. Struct. Mol. Biol.

Network disruptions