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1 keywords

CATH Domain 4lz0A00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.600 Farnesyl Diphosphate Synthase
Homologous Superfamily 1.10.600.10 Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family

Enzyme Information

4.2.3.37
Epi-isozizaene synthase.
based on mapping to UniProt Q9K499
(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate.
-!- The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration. -!- In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC 1.14.13.106 to produce the sesquiterpene antibiotic albaflavenone.

UniProtKB Entries (1)

Q9K499
CYC1_STRCO
Streptomyces coelicolor A3(2)
Epi-isozizaene synthase

PDB Structure

PDB 4LZ0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase.
Li, R., Chou, W.K., Himmelberger, J.A., Litwin, K.M., Harris, G.G., Cane, D.E., Christianson, D.W.
Biochemistry
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