CATH Domain 4fxyP02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1370	Neurolysin; domain 3
	1.10.1370.10	Neurolysin, domain 3

Domain Context

CATH Clusters

Superfamily	Neurolysin, domain 3
Functional Family	Thimet oligopeptidase 1

Enzyme Information

3.4.24.16

Neurolysin.

based on mapping to UniProt P42676

Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.

-!- No absolute requirement for a prolyl bond; the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do. -!- Belongs to peptidase family M3.

UniProtKB Entries (1)

P42676

NEUL_RAT

Rattus norvegicus

Neurolysin, mitochondrial

PDB Structure

PDB	4FXY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Allosteric inhibition of the neuropeptidase neurolysin. Hines, C.S., Ray, K., Schmidt, J.J., Xiong, F., Feenstra, R.W., Pras-Raves, M., de Moes, J.P., Lange, J.H., Melikishvili, M., Fried, M.G., Mortenson, P., Charlton, M., Patel, Y., Courtney, S.M., Kruse, C.G., Rodgers, D.W. J.Biol.Chem.

Network disruptions