CATH Domain 4bfrA01

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.20	Ubiquitin-like (UB roll)
	3.10.20.90	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Superfamily	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Functional Family

2.7.1.153

Phosphatidylinositol-4,5-bisphosphate 3-kinase.

based on mapping to UniProt Q8BTI9

ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.

-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.

PK3CB_MOUSE

Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

PDB	4BFR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and Optimization of Pyrimidone Indoline Amide Pi3Kbeta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers. Certal, V., Carry, J.B., Halley, F., Virone-Oddos, A., Thompson, F., Filoche-Romme, B., El-Ahmad, Y., Karlsson, A., Charrier, V., Delorme, C., Rak, A., Abecassis, P., Amara, C., Vincent, L., Bonnevaux, H., Nicolas, J., Mathieu, M., Bertrand, T., Marquette, J., Michot, N., Benard, T., Perrin, M., Lemaitre, O., Guerif, S., Perron, S., Monget, S., Gruss-Leleu, F., Doerflinger, G., Guizani, H., Brollo, M., Delbarre, L., Bertin, L., Richepin, P., Loyau, V., Garcia-Echeverria, C., Lengauer, C., Schio, L. J.Med.Chem.