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1 keywords

CATH Domain 3p92E00

CATH Classification

Level CATH Code Description
Class 4 Few Secondary Structures
Architecture 4.10 Irregular
Topology 4.10.410 Factor Xa Inhibitor
Homologous Superfamily 4.10.410.10 Pancreatic trypsin inhibitor Kunitz domain

Domain Context

CATH Clusters

Superfamily Pancreatic trypsin inhibitor Kunitz domain
Functional Family Pancreatic trypsin inhibitor

Enzyme Information

UniProtKB Entries (2)

P35030
TRY3_HUMAN
Homo sapiens
Trypsin-3
P00974
BPT1_BOVIN
Bos taurus
Pancreatic trypsin inhibitor

PDB Structure

PDB 3P92
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The P2' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity.
Salameh, M.A., Soares, A.S., Hockla, A., Radisky, D.C., Radisky, E.S.
Biochem.J.
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