CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.650 | Cupin |
Domain Context
CATH Clusters
| Superfamily | Cupin |
| Functional Family | tRNA wybutosine-synthesizing protein 5 |
Enzyme Information
| 1.14.11.42 |
tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase.
based on mapping to UniProt A2RUC4
7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O(2) = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO(2).
-!- The enzyme is not active with wybutosine.
|
UniProtKB Entries (1)
| A2RUC4 |
TYW5_HUMAN
Homo sapiens
TRNA wybutosine-synthesizing protein 5
|
PDB Structure
| PDB | 3AL5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification.
Nucleic Acids Res.
|
