CATH Domain 2xi7D00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.91	Restriction Endonuclease
	3.40.91.60

Domain Context

CATH Clusters

Superfamily	3.40.91.60
Functional Family	RNA-directed RNA polymerase L

Enzyme Information

2.7.7.48	RNA-directed RNA polymerase. based on mapping to UniProt A5HC98 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
3.1.-.-	Acting on ester bonds. based on mapping to UniProt A5HC98

UniProtKB Entries (1)

L_BUNLC

La Crosse virus

RNA-directed RNA polymerase L

PDB Structure

PDB	2XI7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral CAP-Dependent Transcription. Reguera, J., Weber, F., Cusack, S. Plos Pathog.