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1 keywords

CATH Domain 2phiB00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.90 Phospholipase A2
Homologous Superfamily 1.20.90.10 Phospholipase A2 domain

Domain Context

CATH Clusters

Superfamily Phospholipase A2 domain
Functional Family

Enzyme Information

3.1.1.4
Phospholipase A(2).
based on mapping to UniProt P00592
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
-!- Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.

UniProtKB Entries (1)

P00592
PA21B_PIG
Sus scrofa
Phospholipase A2, major isoenzyme

PDB Structure

PDB 2PHI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of a porcine pancreatic phospholipase A2 mutant. A large conformational change caused by the F63V point mutation.
Thunnissen, M.M., Franken, P.A., de Haas, G.H., Drenth, J., Kalk, K.H., Verheij, H.M., Dijkstra, B.W.
J.Mol.Biol.
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