CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Dihydroflavonol reductase |
Enzyme Information
| 1.1.1.219 |
Dihydroflavanol 4-reductase.
based on mapping to UniProt P51110
A (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-dihydroflavonol + NADPH.
-!- This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)- dihydromyricetin, although some enzymes may act only on a subset of these compounds. -!- Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4- diol. -!- NAD(+) can act instead of NADP(+), but more slowly.
|
| 1.1.1.234 |
Flavanone 4-reductase.
based on mapping to UniProt P51110
(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + NADPH.
-!- Involved in the biosynthesis of 3-deoxyanthocyanidins from flavanones such as naringenin or eriodictyol.
|
UniProtKB Entries (1)
| P51110 |
DFRA_VITVI
Vitis vinifera
Dihydroflavonol 4-reductase
|
PDB Structure
| PDB | 2IOD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Binding of two substrate analogue molecules to dihydroflavonol-4-reductase alters the functional geometry of the catalytic site
To be Published
|
