CATH Domain 1h3aA02

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.50	Alpha/alpha barrel
	1.50.10	Glycosyltransferase
	1.50.10.20

Domain Context

CATH Clusters

Superfamily	1.50.10.20
Functional Family

Enzyme Information

5.4.99.17	Squalene--hopene cyclase. based on mapping to UniProt P33247 Squalene = hop-22(29)-ene. -!- The enzyme also produces the cyclization product hopan-22-ol by addition of water (cf. EC 4.2.1.129). -!- Hopene and hopanol are formed at a constant ratio of 5:1.
4.2.1.129	Squalene--hopanol cyclase. based on mapping to UniProt P33247 Hopan-22-ol = squalene + H(2)O. -!- The enzyme produces the cyclization products hopene (cf. EC 5.4.99.17) and hopanol from squalene at a constant ratio of 5:1.

UniProtKB Entries (1)

SQHC_ALIAD

Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446

Squalene--hopene cyclase

PDB Structure

PDB	1H3A
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase Lenhart, A., Reinert, D.J., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E. J.Med.Chem.