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1 keywords

CATH Domain 1f7bA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.20 Alpha-Beta Barrel
Topology 3.20.20 TIM Barrel
Homologous Superfamily 3.20.20.70 Aldolase class I

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family N-acetylneuraminate lyase

Enzyme Information

4.1.3.3
N-acetylneuraminate lyase.
based on mapping to UniProt P44539
N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.
-!- Also acts on N-glycoloylneuraminate, and on O-acetylated sialic acids, other than 4-O-acetylated derivatives.

UniProtKB Entries (1)

P44539
NANA_HAEIN
Haemophilus influenzae Rd KW20
N-acetylneuraminate lyase

PDB Structure

PDB 1F7B
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme.
Barbosa, J.A.R.G., Smith, B.J., DeGori, R., Ooi, H.C., Marcuccio, S.M., Campi, E.M., Jackson, W.R., Brossmer, R., Sommer, M., Lawrence, M.C.
J.Mol.Biol.
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