CATH Domain 1e9aA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Thymidylate kinase

Enzyme Information

2.7.4.9

dTMP kinase.

based on mapping to UniProt P23919

ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

KTHY_HUMAN

Homo sapiens

Thymidylate kinase

PDB Structure

PDB	1E9A
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reintein, J., Goody, R.S., Konrad, M., Schlichting, I. J.Mol.Biol.