The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
ATP:guanido phosphotransferase, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: creatine kinase S-type, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Creatine kinase activity GO:0004111
Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+).
10 P12532 (/TAS) P12532 (/TAS) P12532 (/TAS) P12532 (/TAS) P17540 (/TAS) P17540 (/TAS) P17540 (/TAS) P17540 (/TAS) Q6P8J7 (/TAS) Q6P8J7 (/TAS)
Creatine kinase activity GO:0004111
Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+).
2 P30275 (/ISO) P30275 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P30275 (/IPI) P30275 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P30275 (/ISO) P30275 (/ISO)
Cardiolipin binding GO:1901612
Interacting selectively and non-covalently with cardiolipin.
2 Q6P8J7 (/ISO) Q6P8J7 (/ISO)
Creatine kinase activity GO:0004111
Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+).
1 P25809 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P25809 (/IDA)
Cardiolipin binding GO:1901612
Interacting selectively and non-covalently with cardiolipin.
1 P09605 (/IDA)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Creatine metabolic process GO:0006600
The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.
8 P12532 (/TAS) P12532 (/TAS) P12532 (/TAS) P12532 (/TAS) P17540 (/TAS) P17540 (/TAS) P17540 (/TAS) P17540 (/TAS)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
4 P17540 (/TAS) P17540 (/TAS) P17540 (/TAS) P17540 (/TAS)
Phosphocreatine metabolic process GO:0006603
The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle.
2 Q6P8J7 (/TAS) Q6P8J7 (/TAS)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
2 P09605 (/IEP) P25809 (/IEP)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
2 P30275 (/IDA) P30275 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P30275 (/IGI) P30275 (/IGI)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 P25809 (/IEP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P25809 (/IEP)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 P09605 (/IEP)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 P25809 (/IEP)
Digestive tract development GO:0048565
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
1 P25809 (/IEP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
8 P17540 (/HDA) P17540 (/HDA) P17540 (/HDA) P17540 (/HDA) P30275 (/HDA) P30275 (/HDA) Q6P8J7 (/HDA) Q6P8J7 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
8 P12532 (/TAS) P12532 (/TAS) P12532 (/TAS) P12532 (/TAS) P17540 (/TAS) P17540 (/TAS) P17540 (/TAS) P17540 (/TAS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
8 P12532 (/TAS) P12532 (/TAS) P12532 (/TAS) P12532 (/TAS) P17540 (/TAS) P17540 (/TAS) P17540 (/TAS) P17540 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 P25809 (/IDA) P30275 (/IDA) P30275 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P30275 (/ISO) P30275 (/ISO)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
2 P30275 (/ISO) P30275 (/ISO)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
2 P30275 (/HDA) P30275 (/HDA)
Contact site GO:0044289
Sites of close apposition of the inner and outer mitochondrial membrane.
2 P30275 (/ISO) P30275 (/ISO)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 P25809 (/IDA)
Contact site GO:0044289
Sites of close apposition of the inner and outer mitochondrial membrane.
1 P25809 (/IDA)
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