CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1170.60
Functional Family DNA polymerase iota

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9UNA4
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9UNA4
POLI_HUMAN
Homo sapiens
DNA polymerase iota

PDB Structure

PDB 5ULX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-iota.
Jain, R., Choudhury, J.R., Buku, A., Johnson, R.E., Prakash, L., Prakash, S., Aggarwal, A.K.
Sci Rep