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1 keywords

CATH Domain 5broA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.379 Chitobiase; domain 2
Homologous Superfamily 3.30.379.10 Chitobiase/beta-hexosaminidase domain 2-like

Domain Context

CATH Clusters

Superfamily Chitobiase/beta-hexosaminidase domain 2-like
Functional Family Beta-hexosaminidase subunit beta

Enzyme Information

3.2.1.52
Beta-N-acetylhexosaminidase.
based on mapping to UniProt P07686
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
-!- Acts on N-acetylglucosides and N-acetylgalactosides. -!- Formerly EC 3.2.1.29 and EC 3.2.1.30.

UniProtKB Entries (1)

P07686
HEXB_HUMAN
Homo sapiens
Beta-hexosaminidase subunit beta

PDB Structure

PDB 5BRO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Protease-resistant modified human beta-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.
Kitakaze, K., Mizutani, Y., Sugiyama, E., Tasaki, C., Tsuji, D., Maita, N., Hirokawa, T., Asanuma, D., Kamiya, M., Sato, K., Setou, M., Urano, Y., Togawa, T., Otaka, A., Sakuraba, H., Itoh, K.
J.Clin.Invest.
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