CATH Domain 4rt7A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	receptor-type tyrosine-protein kinase FLT3

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P36888

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P36888

FLT3_HUMAN

Homo sapiens

Receptor-type tyrosine-protein kinase FLT3

PDB Structure

PDB	4RT7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397. Smith, C.C., Zhang, C., Lin, K.C., Lasater, E.A., Zhang, Y., Massi, E., Damon, L.E., Pendleton, M., Bashir, A., Sebra, R., Perl, A., Kasarskis, A., Shellooe, R., Tsang, G., Carias, H., Powell, B., Burton, E.A., Matusow, B., Zhang, J., Spevak, W., Ibrahim, P.N., Le, M.H., Hsu, H.H., Habets, G., West, B.L., Bollag, G., Shah, N.P. Cancer Discov