CATH Domain 4ol8B03

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.270	Reverse transcriptase/Diguanylate cyclase domain

Domain Context

CATH Clusters

Superfamily	3.30.70.270
Functional Family	Transposon Ty3-G Gag-Pol polyprotein

Enzyme Information

2.7.7.49	RNA-directed DNA polymerase. based on mapping to UniProt Q99315 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt Q99315 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.1.26.4	Ribonuclease H. based on mapping to UniProt Q99315 Endonucleolytic cleavage to 5'-phosphomonoester. -!- Acts on RNA-DNA hybrids.
3.4.23.-	Aspartic endopeptidases. based on mapping to UniProt Q99315

UniProtKB Entries (1)

YG31B_YEAST

Saccharomyces cerevisiae S288C

Transposon Ty3-G Gag-Pol polyprotein

PDB Structure

PDB	4OL8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry. Nowak, E., Miller, J.T., Bona, M.K., Studnicka, J., Szczepanowski, R.H., Jurkowski, J., Le Grice, S.F., Nowotny, M. Nat.Struct.Mol.Biol.