CATH Classification

Domain Context

CATH Clusters

Superfamily SET domain
Functional Family

Enzyme Information

2.1.1.-
Methyltransferases.
based on mapping to UniProt Q9NRG4
2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q9NRG4
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

P03372
ESR1_HUMAN
Homo sapiens
Estrogen receptor

PDB Structure

PDB 4O6F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Insights into Estrogen Receptor alpha Methylation by Histone Methyltransferase SMYD2, a Cellular Event Implicated in Estrogen Signaling Regulation.
Jiang, Y., Trescott, L., Holcomb, J., Zhang, X., Brunzelle, J., Sirinupong, N., Shi, X., Yang, Z.
J.Mol.Biol.