CATH Classification

Domain Context

CATH Clusters

Superfamily Zinc/RING finger domain, C3HC4 (zinc finger)
Functional Family lysine-specific demethylase 2B isoform X1

Enzyme Information
[Histone H3]-dimetyl-L-lysine-36 demethylase.
based on mapping to UniProt Q8NHM5
[Protein]-N(6),N(6)-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O(2) = [protein]-L-lysine + 2 succinate + 2 formaldehyde + 2 CO(2).
-!- Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys-36. -!- Lysine residues exist in three methylation states (mono-, di- and trimethylated). -!- The enzyme preferentially demethylates the dimethyl form of Lys-36 (K36me2), which is its natural substrate, to form the monomethyl and unmethylated forms of Lys-36. -!- It can also demethylate the monomethyl- but not the trimethyl form of Lys-36.

UniProtKB Entries (1)

Homo sapiens
Lysine-specific demethylase 2B

PDB Structure

PDB 4O64
External Links
Primary Citation
DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Xu, C., Liu, K., Lei, M., Yang, A., Li, Y., Hughes, T.R., Min, J.