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1 keywords

CATH Domain 4mi5A00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.170 Beta Complex
Topology 2.170.270 Beta-clip-like
Homologous Superfamily 2.170.270.10 SET domain

Domain Context

CATH Clusters

Superfamily SET domain
Functional Family Putative histone-lysine N-methyltransferase EZH2

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q15910
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q15910
EZH2_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase EZH2

PDB Structure

PDB 4MI5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain.
Antonysamy, S., Condon, B., Druzina, Z., Bonanno, J.B., Gheyi, T., Zhang, F., Macewan, I., Zhang, A., Ashok, S., Rodgers, L., Russell, M., Gately Luz, J.
Plos One
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