CATH Classification

Domain Context

CATH Clusters

Superfamily EF-hand
Functional Family Calmodulin-3

Enzyme Information

2.7.11.18
[Myosin light-chain] kinase.
based on mapping to UniProt P11799
ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.
-!- Requires calmodulin for activity. -!- The 20 kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, more slowly. -!- Formerly EC 2.7.1.117.

UniProtKB Entries (3)

P0DP29
CALM1_RAT
Rattus norvegicus
Calmodulin-1
P11799
MYLK_CHICK
Gallus gallus
Myosin light chain kinase, smooth muscle
P42212
GFP_AEQVI
Aequorea victoria
Green fluorescent protein

PDB Structure

PDB 3SG7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Optimization of a GCaMP calcium indicator for neural activity imaging.
Akerboom, J., Chen, T.W., Wardill, T.J., Tian, L., Marvin, J.S., Mutlu, S., Calderon, N.C., Esposti, F., Borghuis, B.G., Sun, X.R., Gordus, A., Orger, M.B., Portugues, R., Engert, F., Macklin, J.J., Filosa, A., Aggarwal, A., Kerr, R.A., Takagi, R., Kracun, S., Shigetomi, E., Khakh, B.S., Baier, H., Lagnado, L., Wang, S.S., Bargmann, C.I., Kimmel, B.E., Jayaraman, V., Svoboda, K., Kim, D.S., Schreiter, E.R., Looger, L.L.
J.Neurosci.