CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.605 | Aldehyde Dehydrogenase; Chain A, domain 1 |
|
3.40.605.10 | Aldehyde Dehydrogenase; Chain A, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Aldehyde Dehydrogenase; Chain A, domain 1 |
| Functional Family | Gamma-glutamyl phosphate reductase |
Enzyme Information
| 2.7.2.11 |
Glutamate 5-kinase.
based on mapping to UniProt P54886
ATP + L-glutamate = ADP + L-glutamate 5-phosphate.
-!- The product rapidly cyclizes to 5-oxoproline and phosphate.
|
| 1.2.1.41 |
Glutamate-5-semialdehyde dehydrogenase.
based on mapping to UniProt P54886
L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH.
|
UniProtKB Entries (1)
| P54886 |
P5CS_HUMAN
Homo sapiens
Delta-1-pyrroline-5-carboxylate synthase
|
PDB Structure
| PDB | 2H5G |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of human pyrroline-5-carboxylate synthetase
To be published
|