CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Protein-tyrosine kinase HTK98, variant

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P43405
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P43405
KSYK_HUMAN
Homo sapiens
Tyrosine-protein kinase SYK

PDB Structure

PDB 4RSS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors.
Choi, J.S., Hwang, H.J., Kim, S.W., Lee, B.I., Lee, J., Song, H.J., Koh, J.S., Kim, J.H., Lee, P.H.
Bioorg.Med.Chem.Lett.