CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Enzyme Information

1.1.1.267
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
based on mapping to UniProt Q9WZZ1
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.

UniProtKB Entries (1)

Q9WZZ1
DXR_THEMA
Thermotoga maritima MSB8
1-deoxy-D-xylulose 5-phosphate reductoisomerase

PDB Structure

PDB 3A06
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding
Takenoya, M., Ohtaki, A., Noguchi, K., Endo, K., Sasaki, Y., Ohsawa, K., Yajima, S., Yohda, M.
J.Struct.Biol.