CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | 3-hydroxybutyryl-CoA dehydrogenase 3-hydroxyacyl-CoA dehydrogenase |
Enzyme Information
| 1.1.1.35 |
3-hydroxyacyl-CoA dehydrogenase.
based on mapping to UniProt Q9ZPI5
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
-!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211).
|
| 5.3.3.8 |
Dodecenoyl-CoA isomerase.
based on mapping to UniProt Q9ZPI5
(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.
-!- Also catalyzes the interconversion of 3-acetylenic fatty acyl thioesters and (+)-2,3-dienoyl fatty acyl thioesters, with fatty acid chain lengths C(6) to C(12).
|
| 4.2.1.17 |
Enoyl-CoA hydratase.
based on mapping to UniProt Q9ZPI5
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O.
-!- Acts in the reverse direction. -!- With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74).
|
| 5.1.2.3 |
3-hydroxybutyryl-CoA epimerase.
based on mapping to UniProt Q9ZPI5
(S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.
|
UniProtKB Entries (1)
| Q9ZPI5 |
MFP2_ARATH
Arabidopsis thaliana
Peroxisomal fatty acid beta-oxidation multifunctional protein MFP2
|
PDB Structure
| PDB | 2WTB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The Multi-Functional Protein in Peroxisomal Beta-Oxidation. Structure and Substrate Specificity of the Arabidopsis Thaliana Protein, Mfp2
J.Biol.Chem.
|