CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family O-methyltransferase family protein, expressed

Enzyme Information

2.1.1.65
Licodione 2'-O-methyltransferase.
based on mapping to UniProt P93324
S-adenosyl-L-methionine + licodione = S-adenosyl-L-homocysteine + 2'-O- methyllicodione.
-!- As well as licodione (1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)- 1,3-propanedione), the 2''-hydroxy-derivative and isoliquiritigenin can act as acceptors, more slowly.
2.1.1.154
Isoliquiritigenin 2'-O-methyltransferase.
based on mapping to UniProt P93324
S-adenosyl-L-methionine + isoliquiritigenin = S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin.
-!- Not identical to EC 2.1.1.65. -!- While EC 2.1.1.154 can use licodione as a substrate, EC 2.1.1.65 cannot use isoliquiritigenin as a substrate.

UniProtKB Entries (1)

P93324
CHOMT_MEDSA
Medicago sativa
Isoliquiritigenin 2'-O-methyltransferase

PDB Structure

PDB 1FP1
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases.
Zubieta, C., He, X.Z., Dixon, R.A., Noel, J.P.
Nat.Struct.Biol.