CATH Domain 1fp1D02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family	O-methyltransferase family protein, expressed

Enzyme Information

2.1.1.65	Licodione 2'-O-methyltransferase. based on mapping to UniProt P93324 S-adenosyl-L-methionine + licodione = S-adenosyl-L-homocysteine + 2'-O- methyllicodione. -!- As well as licodione (1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)- 1,3-propanedione), the 2''-hydroxy-derivative and isoliquiritigenin can act as acceptors, more slowly.
2.1.1.154	Isoliquiritigenin 2'-O-methyltransferase. based on mapping to UniProt P93324 S-adenosyl-L-methionine + isoliquiritigenin = S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin. -!- Not identical to EC 2.1.1.65. -!- While EC 2.1.1.154 can use licodione as a substrate, EC 2.1.1.65 cannot use isoliquiritigenin as a substrate.

UniProtKB Entries (1)

CHOMT_MEDSA

Medicago sativa

Isoliquiritigenin 2'-O-methyltransferase

PDB Structure

PDB	1FP1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases. Zubieta, C., He, X.Z., Dixon, R.A., Noel, J.P. Nat.Struct.Biol.