The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

ClpX chaperone, C4-type zinc finger domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: ClpX chaperone, C4-type zinc finger domain

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead they can bind other metals, or no metal at all. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), but now they are recognised to bind DNA, RNA, protein and/or lipid substrates PMID:10529348,PMID:15963892,PMID:15718139,PMID:17210253,PMID:12665246.

The ClpX heat shock protein of Escherichia coli is a member of the universally conserved Hsp100 family of proteins. ClpX is an ATPase which functions both as a substrate specificity component of the ClpXP protease and as a molecular chaperone. Structural domains comprising this superfamily share the structure of the N-terminal zinc finger domain. This domain is of the C4 type PMID:11278349 and is a member of the treble clef zinc finger family, a motif known to facilitate protein-ligand, protein-DNA, and protein-protein interactions and forms a constitutive dimer that is essential for the degradation of some, but not all, ClpX substrates PMID:14525985.

GO Diversity

Unique GO annotations
17 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
11472 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 6
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC:
Unique GO: 17
Unique Species: 11472