The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Ribosomal protein L6, alpha-beta domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ribosomal protein L6

L6 is a protein from the large (50S) subunit. In Escherichia coli, it is located in the aminoacyl-tRNA binding site of the peptidyltransferase centre, and is known to bind directly to 23S rRNA. The superfamily includes ribosomal proteins from several species, including L6 from bacteria, cyanelles (structures that perform similar functions to chloroplasts, but have structural and biochemical characteristics of Cyanobacteria) and mitochondria, as well as L9 from mammals, Drosophila, plants and yeast.

L6 contains two domains with almost identical folds, suggesting that is was derived by the duplication of an ancient RNA-binding protein gene. Analysis reveals several sites on the protein surface where interactions with other ribosome components may occur, the N terminus being involved in protein-protein interactions and the C-terminus containing possible RNA-binding sites. This alpha-beta domain found duplicated in ribosomal L6 proteins consists of two beta-sheets and one alpha-helix packed around single core.

PFAM:PF00347, INTERPRO:IPR036789,PMID:8262035

GO Diversity

Unique GO annotations
43 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
17547 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 777
Domain clusters (>95% seq id): 30
Domain clusters (>35% seq id): 12
Unique PDBs: 389
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 38
Unique EC:
Unique GO: 43
Unique Species: 17547