The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

Actin; Chain A, domain 4

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: ATPase, substrate binding domain, subdomain 4

This superfamily comprises structural domains found in several ATPases, including actin PFAM:PF00022, INTERPRO:IPR004000, Hsp70 PFAM:PF00012, INTERPRO:IPR013126, BadF/BadG/BcrA/BcrD PFAM:PF01869, various kinases (acetokinase PFAM:PF00871, INTERPRO:IPR000890, hexokinase PFAM:PF00349, INTERPRO:IPR022672, glucokinase PFAM:PF02685, INTERPRO:IPR003836, glycerol kinase), DnaK INTERPRO:IPR012725, ROK PFAM:PF00480, INTERPRO:IPR000600, PilM PFAM:PF11104, INTERPRO:IPR005883, Fumble PFAM:PF03630. Members of this superfamily have two lobes, one with nucleotide binding activity, and a second one with substrate binding activity. The lobes can be structurally divided into 4 subdomains - 1A, 1B, 2A, 2B (or 1, 2, 3, 4). The ATP binding site in these ATPases is well conserved, and is located at the junction of the two lobes, in a deep cleft. This superfamily entry represents subdomain 4 from the substrate binding domain (SBD).


GO Diversity

Unique GO annotations
845 Unique GO terms

EC Diversity

Unique EC annotations
45 Unique EC terms

Species Diversity

Unique species annotations
20945 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 520
Domain clusters (>95% seq id): 40
Domain clusters (>35% seq id): 11
Unique PDBs: 316
Structural Clusters (5A): 3
Structural Clusters (9A): 2
FunFam Clusters: 63
Unique EC: 45
Unique GO: 845
Unique Species: 20945