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CATH Superfamily 3.90.1750.10

Hect, E3 ligase catalytic domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Hect, E3 ligase catalytic domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
E3 ubiquitin-protein ligase NEDD4-like
997
3D
 4be8A01 - 90.7
2
E3 ubiquitin-protein ligase
782
3D
 1nd7A01 - 89.0
3
E3 ubiquitin-protein ligase UPL1
596 - - 95.8
4
E3 ubiquitin-protein ligase HECW2 isoform X1
547 - - 76.0
5
E3 ubiquitin-protein ligase
538
3D
 3olmA01 - 76.1
6
E3 ubiquitin-protein ligase TRIP12 isoform X1
422 - - 67.7
7
E3 ubiquitin-protein ligase SMURF2
420
3D
 1zvdA01 - 81.3
8
Putative ubiquitin-protein ligase E3A
392 - - 83.9
9
E3 ubiquitin-protein ligase HUWE1 isoform X1
381
3D
 3h1dA01 - 69.1
10
probable E3 ubiquitin-protein ligase HERC4 isoform X1
366 - - 68.9
11
E3 ubiquitin-protein ligase UBR5 isoform X1
340 - - 90.4
12
E3 ubiquitin-protein ligase UPL7
296 - - 93.4
13
Apoptosis-resistant E3 ubiquitin protein ligase 1
285 - - 82.5
14
Putative Ubiquitin-protein ligase E3C
262 - - 94.2
16
E3 ubiquitin-protein ligase UBR5 isoform X2
252 - - 51.1
15
E3 ubiquitin-protein ligase HERC2 isoform X2
252 - - 71.9
17
Ubiquitin-protein ligase E3B
243 - - 70.5
18
E3 ubiquitin-protein ligase HECTD1 isoform X1
238 - - 72.2
19
E3 ubiquitin-protein ligase HACE1 isoform X1
228 - - 64.7
20
LOW QUALITY PROTEIN: probable E3 ubiquitin-protein ligase HERC1
191 - - 30.6
21
E3 ubiquitin-protein ligase HECTD1 isoform X1
187 - - 75.5
22
probable E3 ubiquitin-protein ligase HECTD4 isoform X1
157 - - 42.9
23
probable E3 ubiquitin-protein ligase HECTD2 isoform X2
140 - - 83.0
24
E3 ubiquitin-protein ligase
124 - - 49.6
25
Putative E3 ubiquitin-protein ligase HECTD3
108 - - 77.4
26
E3 ubiquitin-protein ligase HACE1
85 - - 99.0
27
HECT and RLD domain containing E3 ubiquitin protein ligase 5
83 - - 64.4
28
HECT E3 ubiquitin ligase
76 - - 84.1
29
Circadian trip, isoform C
52 - - 37.0
30
IQ and HECT domain protein
44 - - 47.2
31
E3 ubiquitin-protein ligase TOM1
35 - - 78.4
32
E3 ubiquitin-protein ligase UPL5
32 - - 72.5
33
E3 ubiquitin-protein ligase hecd-1
28 - - 72.8
34
E3 ubiquitin-protein ligase
28 - - 11.9
36
E3 ubiquitin-protein ligase HECW2
25 - - 70.8
35
Circadian trip, isoform F
25 - - 37.1
37
Apoptosis resistant E3 ubiquitin protein ligase 1
18 - - 23.7
38
Ubiquitin-protein ligase, putative
18 - - 7.4
39
Ubiquitin-protein ligase, putative
17 - - 93.1
40
E3 ubiquitin-protein ligase
15 - - 1.7
41
Ubiquitin ligase
E3
14 - - 80.0
43
E3 ubiquitin-protein ligase UPL1
14 - - 7.8
42
E3 ubiquitin-protein ligase HECTD1
14 - - 38.2
44
E3 ubiquitin-protein ligase Ufd4
12 - - 75.1
45
Ubiquitin ligase e3
11 - - 42.7
48
E3 ubiquitin-protein ligase UPL3
10 - - 66.7
46
Hyperplastic disks-like protein
10 - - 54.9
47
HECT, C2 and WW domain-containing E3 ubiquitin protein ligase 1
10 - - 24.3
49
G2/M phase-specific E3 ubiquitin-protein ligase
9 - - 36.2
50
E3 ubiquitin-protein ligase hecd-1
9 - - 8.3
51
Ubiquitin protein ligase, putative
8 - - 12.5
52
Zn-finger_in_Ran_binding_protein_and_others/SPRY_domain/HECT-domain_
Ubiquitin-transferase
8 - - 11.7
55
Uncharacterized protein, isoform A
7 - - 11.6
53
Ubiquitin protein ligase, putative
7 - - 1.6
54
Ubiquitin protein ligase, putative
7 - - 12.9
56
Ubiquitin ligase, putative
6 - - 0.7
58
Uncharacterized protein
6 - - 94.6
57
HECT-domain
Ubiquitin-transferase
6 - - 40.8
60
Uncharacterized protein
5 - - 11.1
59
Uncharacterized protein
5 - - 80.0
61
E3 ubiquitin-protein ligase hecw-1
4 - - 16.8
68
Putative E3 ubiquitin-protein ligase TRIP12-like
3 - - 43.7
69
HECT E3 ubiquitin ligase
3 - - 14.2
63
Putative E3 ubiquitin-protein ligase HECTD4
3 - - 19.9
62
Predicted protein
3 - - 44.2
79
E3 ubiquitin-protein ligase
3 - - 38.2
70
Hect domain and RLD 3
3 - - 0.0
71
E3 ubiquitin-protein ligase hyd
3 - - 0.0
64
E3 ubiquitin-protein ligase HACE1
3 - - 10.5
65
HECT-domain ubiquitin--protein ligase E3
3 - - 6.4
66
E3 ubiquitin-protein ligase UBR5 isoform X1
3 - - 36.7
72
Uncharacterized protein
3 - - 44.9
67
Uncharacterized protein
3 - - 71.7
78
Ubiquitin-protein ligase, putative
2 - - 36.6
80
Uncharacterized protein
2 - - 51.6
82
Apoptosis-resistant E3 ubiquitin protein ligase 1
2 - - 0.7
81
Uncharacterized protein
2 - - 18.7
76
UBR E3 ubiquitin ligase homolog
2 - - 25.6
84
Uncharacterized protein
2 - - 0.0
77
Uncharacterized protein
2 - - 27.0
83
Zn-finger in Ran binding protein and others/SPRY domain/HECT-domain
Ubiquitin-transferase
2 - - 0.0
85
Predicted protein
2 - - 39.8
74
Putative ubiquitin-protein ligase e3c
2 - - 0.0
75
Uncharacterized protein
2 - - 29.3
73
Uncharacterized protein
2 - - 5.3
112
Uncharacterized protein
1 - - 0.0
89
Predicted protein
1 - - 0.0
91
Predicted protein
1 - - 0.0
92
Uncharacterized protein
1 - - 0.0
105
Ubiquitin-protein ligase E3 C
1 - - 0.0
111
Predicted protein
1 - - 0.0
113
Uncharacterized protein
1 - - 0.0
99
Predicted protein
1 - - 0.0
90
Uncharacterized protein
1 - - 0.0
110
Uncharacterized protein
1 - - 0.0
102
E3 ubiquitin-protein ligase
1 - - 0.0
118
Uncharacterized protein
1 - - 0.0
100
Uncharacterized protein
1 - - 0.0
93
Ubiquitin-protein ligase, putative
1 - - 0.0
103
Predicted protein
1 - - 0.0
101
Uncharacterized protein
1 - - 0.0
96
Predicted protein
1 - - 0.0
116
Uncharacterized protein
1 - - 0.0
108
Uncharacterized protein
1 - - 0.0
117
Uncharacterized protein
1 - - 0.0
94
E3 ubiquitin-protein ligase
1 - - 0.0
109
Uncharacterized protein
1 - - 0.0
95
Predicted protein
1 - - 0.0
106
E3 ubiquitin-protein ligase
1 - - 0.0
86
Uncharacterized protein
1 - - 0.0
98
Predicted protein
1 - - 0.0
107
Uncharacterized protein
1 - - 0.0
87
Uncharacterized protein
1 - - 0.0
115
Uncharacterized protein
1 - - 0.0
114
Predicted protein
1 - - 0.0
104
Protein CBR-HECD-1
1 - - 0.0
97
E3 ubiquitin-protein ligase UPL5
1 - - 0.0
88
Uncharacterized protein
1 - - 0.0