The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Aminoglycoside phosphotransferase (APH), C-terminal lobe

Aminoglycosides are one of the oldest classes of antibiotics, first discovered in 1944. Despite their long history as potent antibacterials, unfortunately they do not meet their full potential as clinical drugs, largely due to antibiotic resistance. Aminoglycoside resistance enzymes include aminoglycoside acetyltransferases (AAC) and aminoglycoside phosphotransferases or kinases (APH). The APH enzymes belong to the eukaryotic-type protein kinase (PK) superfamily. This group also contains serine/threonine and tyrosine PKs and small-molecule kinases like choline kinase. Outside of the nucleoside-binding and catalytic site, APH enzymes deviate considerably in architecture from PKs, most notably by a large expansion of the C-terminal lobe. This expansion divides the C lobe into the "core subdomain" shared with PKs that contains all of the catalytic elements, and the APH-specific "helical subdomain" PMID:27161980.

This entry represents the C-terminal lobe of APH enzymes. This domain is composed of two central 4-helical bundles, a short beta hairpin and a small two-stranded beta sheet PMID:25619172.

GO Diversity

Unique GO annotations
95 Unique GO terms

EC Diversity

Unique EC annotations
17 Unique EC terms

Species Diversity

Unique species annotations
17280 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 298
Domain clusters (>95% seq id): 32
Domain clusters (>35% seq id): 22
Unique PDBs: 135
Structural Clusters (5A): 2
Structural Clusters (9A): 2
FunFam Clusters: 87
Unique EC: 17
Unique GO: 95
Unique Species: 17280