The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.
Domain II contains three-stranded and two-stranded anti-parallel beta-sheets, located at approximately right angle to each other, and two alpha-helices between them. It is located on the outer side of the ribosome body between the C-terminal domain of L6, the N-terminal domain of L11, and the H42-H44 region of 23S rRNA.
The large ribosomal subunit contains a highly flexible and functionally important lateral protuberance called the "stalk" (L7/L12 stalk in Bacteria, L12 stalk in Archaea, and P1/P2 stalk in Eukarya). The stalk is involved in the formation of the so-called "GTPase-associated site" and plays a key role in the interaction of ribosome with translation factors and in the control of translation accuracy. The L7/12 stalk is formed by two or three copies of the L7/L12 dimer bound to the C-terminal tail of protein L10. The N-terminal domain of L10 binds to a segment of domain II of 23S rRNA near the binding site for ribosomal protein L11. This superfamily includes the N-terminal domain of L10 in bacteria, and the domain II from the N-terminal fragment characterised in archaea. It is important to note that domain II of MjaL10NTF (insertion in domain I) is absent in bacteria.
|Domain clusters (>95% seq id):||3|
|Domain clusters (>35% seq id):||2|
|Structural Clusters (5A):||1|
|Structural Clusters (9A):||1|