The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ribosomal protein L10, N-terminal fragment, domain II

This superfamily comprises the N-terminal domain II of the ribosomal protein L10 found in the large subunit (50S) of the ribosome. The entry contains homologues such as archaebacterial acidic ribosomal protein P0 homologue (L10E) and the eukaryotic 60S ribosomal protein P0 (L10E). The RNA-binding domain and the adjacent domain are thought to exist in archaeal L10 and eukaryotic P0 proteins only.

Domain II contains three-stranded and two-stranded anti-parallel beta-sheets, located at approximately right angle to each other, and two alpha-helices between them. It is located on the outer side of the ribosome body between the C-terminal domain of L6, the N-terminal domain of L11, and the H42-H44 region of 23S rRNA.

The large ribosomal subunit contains a highly flexible and functionally important lateral protuberance called the "stalk" (L7/L12 stalk in Bacteria, L12 stalk in Archaea, and P1/P2 stalk in Eukarya). The stalk is involved in the formation of the so-called "GTPase-associated site" and plays a key role in the interaction of ribosome with translation factors and in the control of translation accuracy. The L7/12 stalk is formed by two or three copies of the L7/L12 dimer bound to the C-terminal tail of protein L10. The N-terminal domain of L10 binds to a segment of domain II of 23S rRNA near the binding site for ribosomal protein L11. This superfamily includes the N-terminal domain of L10 in bacteria, and the domain II from the N-terminal fragment characterised in archaea. It is important to note that domain II of MjaL10NTF (insertion in domain I) is absent in bacteria.

PFAM:PF00466, INTERPRO:IPR001790,PMID:20399793

GO Diversity

Unique GO annotations
210 Unique GO terms

EC Diversity

Unique EC annotations
7 Unique EC terms

Species Diversity

Unique species annotations
2034 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 7
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 2
Unique PDBs: 6
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC: 7
Unique GO: 210
Taxonomy
Unique Species: 2034