The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

GpdQ, catalytic alpha/beta sandwich domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: GpdQ, catalytic alpha/beta sandwich domain

This superfamily includes the glycerophosphodiesterase (GDPD) from Enterobacter aerogenes, GpdQ, a promiscuous binuclear metallohydrolase that belongs to a diverse family of metallo-phosphoesterases. It plays a role in catalysing the hydrolysis of mono-, di- and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents.

This entry describes the catalytic alpha/beta sandwich domain, which consists of two facing beta-sheets, surrounded by alpha-helices. The entry also contains the final helix of the domain swapped extension, which forms a 'cap' at the alpha/beta sandwich sub-domain, which significantly narrows the entrance to the active site cavity.


GO Diversity

Unique GO annotations
0 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
1050 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 14
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 5
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 1
Unique GO:
Unique Species: 1050