The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Metallo-beta-lactamase domain

Structural domains comprising this superfamily share the structure of the metallo-beta-lactamase (MBL) domain which is found in several proteins which, besides beta-lactamases and metallo-beta-lactamases, include several other metalloenzymes such as alkyl sulphatase. The alkyl sulphatase SdsA1 is a representative of the metallo-beta-lactamase fold.

Enzymes containing this domain are mostly hydrolases. The metal-binding end, with the exception for the Zn2+-binding loops, is responsible for substrate recognition and, therefore, unique to each enzyme. The MBL fold is stable scaffold that has been used repeatedly during evolution to catalyze a diverse range of chemical reactions. Structurally, this diversity is achieved by varying the sequence and length of loops near the active site, which allows the accommodation of various substrates. Combination of the MBL domain with auxiliary substrate-, product- or cofactor-binding domains, have greatly extended the range of functions of proteins containing this domain PMID:16684886.

GO Diversity

Unique GO annotations
5 Unique GO terms

EC Diversity

Unique EC annotations
4 Unique EC terms

Species Diversity

Unique species annotations
1900 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 29
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 1
Unique PDBs: 12
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 4
Unique GO: 5
Unique Species: 1900